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The right PentaHibe for your cryopreservation process

A natural carbohydrate-based cryoprotective agent offering proven efficacy with reduced toxicity compared to high concentrations of DMSO, PentaHibe comes in a number of formulations to suit your needs.

PentaHibe

Complete

Ready-to-use

PentaHibe Complete is a ready-to-use cGMP compliant formulation that can be used with a range of cell types. With 10% pentaisomaltose and 2% DMSO as cryoprotective agents, PentaHibe Complete significantly reduces DMSO-related toxicity and side effects.

cGMP manufactured
Reduced % of DMSO
Sterile
Serum-free
Low endotoxins
Water-like viscosity

Improved outcomes

PentaHibe Complete, containing 2% DMSO, shows comparable results to commercially available cryosolutions with higher DMSO concentration and even demonstrates superior migratory potential.4,5

Enhanced safety

PentaHibe Complete, containing 2% DMSO, minimizes cellular toxicity and DMSO-related side effects, enhancing both safety and effectiveness vs. traditional DMSO-based cryopreservation methods.1

Tested on several cell types

PentaHibe Complete, cGMP manufactured, has been tested on T-cells, human mesenchymal stem cells, and CHO cells and comes with comprehensive documentation to support regulatory submissions.

Data & Documents

1 Svalgaard JD et al. Cell Transplantation, 2018 Sept; Vol 27(9): 1407-1412

4 Haastrup EK et al. Transplantation and Apheresis Science, 2021; Vol 60(4): 103138

5 Svalgaard JD et al. Cryobiology, 2020; Vol 96(01): 207-213

Ready-to-use

Readytouse

PentaHibe

Base

For further formulations

PentaHibe Base (40% pentaisomaltose) is a natural, cGMP compliant, non-toxic cryoprotective agent that can be used as the sole cryoprotective agent or as a base for further formulations. In addition to offering complete flexibility, PentaHibe Base can eliminate the need for DMSO or reduce the need for DMSO to 1-2%, which significantly lowers DMSO-related toxicity and side effects.

100% natural
DMSO-free
Xeno-free and animal  component-free
Protein-free
Serum-free

0% DMSO for hematopoietic stem cells

DMSO-free PentaHibe Base can be used as sole CPA for cryopreservation of hematopoietic stem cells and ensures the same recovery as with 10% DMSO2. It has also shown long-term engraftment in mouse models1.

Same efficacy with only 1% DMSO for T cells

10% PentaHibe Base and only 1% DMSO show similar viability and recovery to commercial formulations with 10% DMSO for cryopreservation of T cells4.

Robust safety profile

Preclinical and clinical studies confirm pentaisomaltose’s tolerability in both humans and various animal species, supported by comprehensive pharmaco-toxicological and clinical evidence.

Data & Documents

1 Svalgaard JD et al. Cell Transplantation, 2018 Sept; Vol 27(9): 1407-1412
2 Svalgaard JD et al. Transplantation and Cellular Engineering, 2016 May; Vol 56(5): 1088-1095

4 Haastrup EK et al. Transplantation and Apheresis Science, 2021; Vol 60(4): 103138

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Pharmacosmos A/S
Roervangsvej 30
DK-4300 Holbaek
Denmark

www.pharmacosmos.com

Tel: +45 5948 5959
Email: pentahibe@pharmacosmos.com
Business hours are Monday to Friday 08:00-16:00 CET