
From patient biopsies to advanced organoid models, preserving sample integrity is critical for downstream success. Pentahibe Complete supports reliable organoid establishment and sustained post-thaw growth from cryopreserved biological material as demonstrated in collaboration with the Cambridge Stem cell Institute.
Pentahibe Complete achieved 100% organoid establishment from cryopreserved duodenum, ileum, and colon biopsies, significantly outperforming standard freezing medium with 10% DMSO. With increased organoid count, sustained growth and consistent post-thaw structural preservation, Pentahibe helps deliver the reproducibility and performance organoid workflows depend on.
High-value patient-derived tissue samples are often scarce and difficult to obtain. Pentahibe Complete is designed to preserve the integrity of biobanked tissues – from collection to culture – so that less is lost and more becomes viable organoid material.
Pentahibe Complete supports the transition toward more predictive, human-relevant research models by enabling reliable cryopreservation for organoid workflows. With growing regulatory and scientific focus on New Approach Methodologies (NAMs), including the FDA Modernization Act 2.0, the low-DMSO, cGMP-compliant formulation is designed to support scalable workflows from early discovery through translational research and biobanking.
In partnership with the Zilbauer Group (Cambridge Stem Cell Institute), Pentahibe Complete significantly outperformed conventional 10% DMSO media in preserving patient-derived intestinal biopsies and subsequent organoid generation.

Whether you're optimising an existing organoid programme or building one from scratch, we're here to support you.
Your partner for advancing organoid science

Organoids represent a shift toward more predictive, human-relevant models. At Pharmacosmos, we are investing in this future by collaborating with the scientists and organisations shaping organoid research, supporting new data generation and contributing to the development of scalable and reproducible workflows.
Our work with the Zilbauer Group at the Cambridge Stem Cell Institute is one example of what is possible when academic rigour meets the right cryopreservation solution.
We actively welcome discussions with research labs, biotech companies and clinical institutions working at the forefront of organoid science – whether to generate new data, explore new applications or integrate Pentahibe into established workflows.
Get in touch to discuss collaboration opportunities